Hypervitaminosis-A, Causes Hypothyroidism in Mouse

Abstract

Thyroid gland is unique among vertebrate endocrine glands is that it stores its secretory products i.e. thyroid hormone. The thyroid influence reproduction, growth and differentiation.

Retinol Palmitate (RP) is known for its effects on differentiation and morphogenesis during vertebrate development, as it is important for reproduction development and growth, hyper and hypo-vitaminosis- A both provoke epithelial pathologies in animal and human being. So a critical value of RP is required in vivo for the maintenance of normal architecture and function of many body tissues

Thyroid gland is unique among vertebrate endocrine glands is that it stores its secretory products i.e. thyroid hormone. The thyroid influence reproduction, growth and differentiation.

The group of adult mouse was treated 4 IU/ day concentration of RP by intubations for 7 days. This constituted the treated group. A similar number of mice were considered as controlled group, and were not given any RP treatment. The animal were observed for their growth, behaviour and weight, during the period of treatment

1. On 8^th day of the serum thyroxin level analysis was done to both treated as well as controlled mice.In treated case hypothyroidism was seen.
2. The studies concluded that RP treatment results in a reduced activity of thyroid follicles i.e. reduced synthesis of thyroxin.