Solvent–Free Synthesis and Evaluation of Antimicrobial Activity of Vanadium (III) Metal Complex Using Two Amino Acids as Mixed Ligands

Abstract

Vanadium (III) metal complex was synthesized mechanochemically using L-Leucine and Creatinine as mixed ligands. The metal and the ligands were grinded using an agate mortar with pestle. The compound formed was characterized by melting/decomposition temperature, solubility test, magnetic susceptibility, conductivity measurement and Infrared analysis. The metal – ligand ratios were investigated via Job's method of continuous variation and revealed it to be 1: 1 in the metal complex. The shifts of bands (2959 – 3204 to 3327 in v N – H) and appearance of new bands (671 and 750) in the complex indicates the complexation. The lower conductivity measurement value (32.30) µS.cm^-1 suggested the non-electrolytic nature of the complex. The magnetic effective value of the metal complex (3.83BM) showed that the complex is paramagnetic and octahedral. It was concluded that the amino acids (ligands) coordinated in a bidentate way through the nitrogen from amino group and oxygen from carboxylate. The complex was screened for its antimicrobial activities against two bacterial and one fungalisolate (Streptococcuspneumoniae, Klebsiellapneumoniae and Aspergillus Niger). The complex exhibited good activity against the organisms.