Analysis of Effects of Radiographic Contrast Media (RCM) on Blood Cells of Albino Wistar Rat

Abstract

The purpose of this study was to analyze the effects of Radiographic Contrast Media (RCM) on the status of blood cells of albino Wistar rat. Thirty (30) Wistar rats weighing between 182 – 212 kg were used for the experiment. The animals were grouped into five, consisting of 6 animals per group. 1 group was used as control, while 4 served as experimental receiving low and high dosage of RCM [urografin (diatrizoate) and ultravist (iopromide)]. Collection of blood samples was carried out on the experimental groups at the intervals of 30 minutes, 1 hour, 12 hours and 24 hours. Blood sampling on the experimental groups and control group was carried out simultaneously. Results showed that RCM affect blood cells generally with urografin (ionic) showing sustained effect on platelet and ultravist (non-ionic) with un-pronounced effect on packed cells volume.