Effect of Mechanochemically Synthesized Copper (II) and Silver (I) Complexes on Some Cephalosporin Resistant Bacteria

Abstract

Complexes of Cu (II) and Ag (I) with cefixime and cefradine as ligands have been mechanochemically (solvent free) synthesized and characterized by physico-chemical methods which includes: infrared, UV/Visible, elemental analysis, melting point, solubility and conductivity. Based on the elemental analysis, the complexes were proposed to have the formula [Cu(CFI)2H₂O], [Cu(CFA)2H₂O], [Ag(CFI)NO₃] and [Ag(CFA)NO₃] where CFI = cifixime and CFA = cefradine. The antimicrobial activities of the synthesized complexes were tested using disc diffusion method, against different strains of bacteria such as Strepto coccus pneumonia, Bacillus subtillus, Salmonella typhi, Klebsiellapnuemoniae, Escherichia coli,Methicillin-resistance staphylococcus aureus (MRSA),Pseudomonas aeruginosa and Staphlylococcus aureus. It has been observed that the complexes have higher activity than the free ligand.The IR spectral data indicates that both CFI and CFA coordinate to the metal ion through n(COO) and n(C=O) due to their structural similarities. The melting point, colour and electronic spectra of the complexes were different from that of the ligands, which suggest formation of coordination compounds.