Design, Synthesis and Pharmacological Evaluation of Novel Bis Acid Amides as Antibacterial and Anti-inflammatory Agents
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Abstract
Opening of the five-member ring of dihydrofuran-2,5-dione with amines was used to synthesize a series of amides of4-oxo-4-(substituted) butanoic acid.4-oxo-4-(substituted) butanoic acidamine coupling using 1,1'-carbonyldiimidazole (CDI) was designed to synthesize newbis-acid amide derivatives and pharmacological activities of the compounds were evaluated. Good functional group transformations were observed upon conventional synthesis. Infrared spectroscopy (IR), 1H and 13C nuclear magnetic resonance (NMR) and liquid chromatography-mass spectrometry (LC-MS) analysis were used to establish the structures of the newly synthesized compounds. All the compounds were tested for in-vitro antibacterial and anti-inflammatory activity, some of the compounds were proven to be potent antibacterial and anti-inflammatory agents.