Microwave-Assisted, Palladium Catalyzed Synthesis of Novel 4,6-Diamino Pyrimidine Derivatives
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Abstract
Great challenging second nucleophilic substitution of pyrimidine reaction was achieved by palladium catalyzed coupling reaction at higher temperature under microwave irradiation in closed system using 1,4-dioxane as solvent with high yield. Further, structures of these newly synthesized compounds were confirmed by spectral and elemental analysis.