Computer Abetted Drug Design: New Therapeutic Approach for Development of Target Database

Abstract

In modern drug discovery practices, drug leads are designed against a pre-selected drug target. Rapid discovery of new therapeutic targets is also very important as it may not only introduce more efficient therapeutic targets for certain diseases, but also increase the flexibility in designing of novel therapeutic intervention strategies by exploiting the synergies between known and newly discovered targets. This work begins with the development of the Therapeutic Target Database (TTD), which provides a comprehensive information source of known therapeutic targets. A relational data model was designed specifically for this database which aims to maximize the ability to accommodate future extensions and facilitate the integration of information.