Characterisation and Functional Analysis of A0A022RDQ0 Protein

Abstract

This work seeks to characterise and carry out functional analysis of A0A022RDQ0 protein. Basic Local Alignment Search Tool was used to consider specific similarity hits. Uniprot database was used to check predicted functional similarities and subcellular localization of model proteins. Clustal Omega database was used to obtain phylogenetic tree of all proteins to determine evolutionary relationships. Domain/superfamily/multi-domain hits of model proteins were analysed using NCBI's conserved domain database. Results report that A0A0B2RQU6, G7L0J5, W9SFC3 and A0A0B0P4Q5 proteins respectively show 85.5%, 84.0%, 84.09% and 82.4% similarities to A0A022RDQ0. The four model proteins are ribonucleoproteins that localise in the ribonucleoprotein complex. Phylogenetic tree report that all proteins have similar evolutionary origin. Domain search indicate that all proteins belong to WD40. High similarity in sequence of A0A022RDQ0 to four model proteins as well as similar function, domain, subcellular localization and evolutionary origin of the various proteins suggests that A0A022RDQ0 functions as a ribonucleoprotein.