Role of Hepciden in Multiple Myeloma and Lymphoma Patients

Abstract

Hepcidin-25 is thought to be the central regulator of body iron metabolism. Since the clinical characteristics of the anemias of chronic inflammation are similar to anemia found in cancer, and since several tumor types are associated with increased cytokine production, especially hepcidin has been addressed as an explanation for the associated anemia in these conditions.

14 patients with non-Hodgkin lymphoman, 12 patients with Hodgkin lymphoma and 24 patients with multiple myeloma enrolled in this study. Serum hepciden was measured in all patients using ELISA.

Conclusion. Hepcidin levels are significantly higher in anemic patients with MM, HL and NHL. Hepcidin levels are inversely correlated with Hb levels.